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These results are closer to Mounjaro's effectiveness, with an average weight loss of 22.5% at the maximum maintenance dose of 15 mg per week over 72 weeks

EVOKE+ demonstrated that high-dose oral semaglutide engaged Alzheimers biology, producing favorable shifts in biomarkers of neurodegeneration and neuroinflammation, even though those changes did not translate into measurable clinical benefit over the trial period