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[18] L-carnitine is water-soluble and can be taken with or without food, though some individuals find that taking it with meals reduces gastrointestinal discomfort

Harreiter, J., Roden, M., Diabetes, & MellitusDefinition (2019)

As facial fat diminishes, patients often notice their skin appears thinner, less resilient and less able to bounce back because the underlying collagen network is under greater mechanical stress, she says