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brasiliensis Modulate Inflammatory Response and Increase Bacterial Killing Septic mice showed a significant increase in neutrophil and mononuclear cell recruitment to the peritoneal cavity at 12 h after sepsis induction (Figures 3A,B), as well as high bacterial load (Figure 3C) and increased NO levels (Figure 3E)

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The histological characteristics of IC, including the thinning and erosion of the bladder epithelium, along with heightened infiltration by mast cells, suggest that the condition may stem from the compromised regenerative capacity of the bladders epithelial cells, coupled with anomalies in immune system functioning (Slobodov et al., 2004)