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In individuals with PCOS , insulin resistance and excess weight can interfere with ovulation , making it difficult to conceive

GLP1-E2 monotherapy delayed hyperglycaemia onset by 2 weeks and halted insulitis progression similar to aCD3, without altering peripheral lymphocyte counts, indicating beta cell-mediated modulation of local immune responses

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Sensitivity analyses, conducted after excluding SLE cases, indicated that all but one event (vitreous floaters) remained statistically significant, suggesting that these risks are more likely attributable to HCQ/CQ exposure than to the underlying disease