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doi: 10.1371/journal.pone.0024479 102 FlynnM.DooleyJ

Notably, LPS-induced NF-B activation occurs in two phases: an early phase (0.5-2 hours after stimulation) driven by TLR4 signaling, and a late phase (8-12 hours after stimulation) sustained by cytokines such like TNF- and IL-1 generated during the early phase (81)

The authors emphasize BPC 157's unusual stability and its effects against various gastrointestinal lesions, on the nitric oxide system, somatosensory neurons, endothelium protection, endothelin, and angiogenesis promotion

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