surpass-2 tirzepatide vs semaglutide weight loss Semaglutide: 2026 Clinical Comparison Tirzepatide vs Semaglutide 2026: 22%

Classic presentation of multiple myeloma (CRAB) Hyper C alcemia Usually hypercalemia 2/2 lytic bone lesions R enal insufficiency Especially if calcium HIGH, concerning myeloma Since Ca is usually LOW in renal disease A nemia Lytic B one lesions Additional features: Amyloidosis (Big tongue macroglossia, restrictive cardiomyopathy) Hyperviscosity (e.g., WM) Gum bleeding, Epistaxis and Bruising without other explanation Polyneuropathies Pearl 2: What is our initial workup

Texas Diabetes & Endocrinology notes that GLP-1 agonists can reduce thirst cues as well as appetite, which makes it easier to go outside under-hydrated

These medications slow down the emptying of the stomach, reduce appetite, and increase insulin release, leading to better control over blood sugar levels and fewer food cravings

Headaches Headaches are the most commonly reported side effect, particularly during the first one to two weeks of use

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