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Ethics declarations Competing interests M.J.D has acted as a consultant, advisory board member and speaker for Boehringer Ingelheim, Eli Lilly, Novo Nordisk and Sanofi

14 A 2017 meta-analysis of 52 randomized, controlled trials that evaluated DPP-4 inhibitors' effects on beta-cell function found that, in monotherapy studies, all agents except linagliptin resulted in improvements in cell function

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The main concern is an F BBB rating , which contrasts sharply with the strong Trustpilot performance

Conclusions and Future Perspectives Since the beginning of plant GST research in 1970 the fundamental questions have remained largely unanswered: what are the physiological roles of GST isoenzymes and which metabolites are the natural, endogenous substrates of GSTs