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The expression of these antioxidants is transcriptionally regulated by NRF2 (NF-E2 p45-related factor)

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The histological score has gone up with the increase of AGEs in the Achilles tendon, which indicates that AGEs have caused impaired tendon repair, and the mechanical function of the tendon might also be affected

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This detoxification process is crucial for individuals exposed to environmental pollutants, heavy metals, or those consuming a diet high in processed foods