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Clinical trials have demonstrated that nausea, diarrhea, vomiting, constipation, and abdominal discomfort occur frequently, particularly during dose initiation and escalation

Hypoglycemia Some people with type 2 diabetes can also develop low blood sugar typically defined as below 55 milligrams per deciliter (mg/dL) or 3.1 millimoles per liter (mmol/L) while taking a GLP-1, especially if theyre also on other medications, such as insulin, that can also lower blood sugar levels

doi: 10.1007/s00125-017-4354-8 132 SammsRJCoghlanMPSloopKWSammsRJCoghlanMPSloopKW

To minimise discomfort, eat smaller, more frequent meals, avoid high-fat or spicy foods, and stay well hydrated

In the UK, it is illegal to purchase retatrutide for cosmetic use