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Naunyn-Schmiedeberg's Arch Pharmacol 398 , 1016910177 (2025)

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By far, it has shown the highest average weight loss results in a clinical trial with 22.5% average weight loss at 72 weeks (SURMOUNT-1, NEJM 2022)

This doesnt mean avoiding supplements altogether

Beyond working with a doctor to ensure nutritional benchmarks are met, the recommendations include screening for a history of disordered eating and taking into account a persons whole health before prescribing

A 2024 analysis of semaglutide outcomes found that participants lost an average of 15.3 kg total, of which 5.3 kg was lean mass