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Our hypothesis calls for precision nutrition models that stratify patients based on biochemical profiles and sex-specific responsesgenerating new paradigms for thyroid-CVD comanagement [9]

Impact of Toxins on P450 Enzymes and Methylation Exposure to toxins, drugs, and alcohol can impair the activity of P450 enzymes, leading to a decrease in SAMe production and impaired methylation

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These include: Nausea (affecting 20-40% of patients initially) Vomiting Diarrhoea Constipation Abdominal discomfort These effects typically arise from delayed gastric emptying and direct effects on the gastrointestinal tract