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Since none of the GLP-1RA are approved in pregnancy, a cohort study approved the potency of liraglutide, in early pregnancy, despite its adverse outcomes such as preterm birth, preeclampsia and gestational diabetes mellitus (GDM) (90)

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The pattern is consistent: patients with baseline nutrient deficiencies (common in calorie-restricted diets) show measurably better fat loss velocity when lipotropic support is added, while patients with adequate baseline status see minimal additional benefit

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