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The Dietary Supplement Health and Education Act (DSHEA) of 1994 places the burden of proof on the FDA to show a supplement is unsafe, rather than requiring the manufacturer to prove it is effective

endocrine disease (Type 1 diabetes, hyperthyroidism, hypothyroidism)

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Additionally, these medications enhance glucose-dependent insulin secretion from pancreatic beta cells whilst suppressing inappropriate glucagon release, thereby improving glycaemic control in individuals with type 2 diabetes