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doi: 10.1128/spectrum.02524-22 204 WangY.ChristopherB

Immunosuppressive regimens in lupus frequently include exactly such agents

The peptide demonstrated safety and met primary efficacy endpoints, showing reductions in disease activity scores compared to placebo

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The benefits were strongest in those who had not previously had a stroke or heart attack, and the efficacy remained consistent regardless of baseline folate levels, folic acid dosage, inclusion of other B vitamins, or degree of homocysteine reduction