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Furthermore, the predominance of Unclear risks suggests that while the study design might be sound, the reporting standards need significant improvement to rule out selection and detection biases

Compounded versions claim to have the same active ingredient and efficacy

In animal studies of tramadol, decreased fetal weights and reduced ossification were observed in mice, rats, and rabbits at 1.4, 0.6, and 3.6 times the maximum recommended human daily dosage (MRHD)

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