The mechanisms that allow BPC-157 to repair the gut lining include cell regeneration, angiogenesis, and anti-inflammatory effects
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Another TKI Lenvatinib, also an angiogenesis inhibitor, in combination with ICI therapy has demonstrated a synergistic antitumor effect, as VEGFA inhibition promotes the infiltration and survival of CTLs, and the meantime mitigates recruitment of Treg lymphocytes, leading to the more advantageous immune microenvironment for antitumor activity of ICI therapy (Hilmi et al., 2019)