Top Hyperpigmentation On Tongue Causes Based on the clinical evidence available in the current literature, here are the documented causes of tongue hyperpigmentation organized by category, typical clinical clue, recommended next step, and relevance for patients in post-procedure recovery: Addison's Disease (Adrenal Insufficiency) Typical clue: Diffuse oral and tongue pigmentation with systemic symptoms such as fatigue, weight loss, and skin darkening elsewhere
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