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PHA-665752 inhibits quite specifically c-Met kinase catalytic activity [63]

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Glutathione is sometimes associated with hormonal processes, but it is not the same as a hormone

Therefore the overall impact on fertility that ROS has is not a matter of if it is there or not (as mentioned earlier, some oxidative stress is required for various reproductive physiological functions), but when levels of ROS are too high (or antioxidant levels are too low) it becomes pathological to sperm and the ability to get pregnant

Throughout the experimental period, animals were monitored daily for signs of distress, including severe lethargy, impaired mobility, abnormal posture, or inability to access food and water