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Despite existing treatment options, there is still a clear unmet need for this group

Lampariello, L

Immediate medical attention (via NHS 111 or emergency services) is required if patients develop: Severe, persistent abdominal pain (possible pancreatitis) Marked reduction in urine output or complete cessation Confusion or altered consciousness Severe allergic reactions (rash, difficulty breathing, facial swelling) Healthcare professionals should establish clear safety-netting arrangements , ensuring patients understand when and how to seek help

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Clinicians may adjust hydration advice, check bloodwork sooner, or delay dose increases if these appear