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J Chem Technol Biot 92(8):21502158

We hypothesized that a program of caloric restriction plus SAR425899, compared to caloric restriction alone, would attenuate of the expected fall in SMR (reduced metabolic adaptation) and stimulate fat oxidation

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Insulin Signal Transduction All of the post-receptor responses initiated by insulin binding to its receptor are mediated as a consequence of the activation of several divergent and/or intersecting signal transduction pathways