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In pancreatic cancer cells, oncogenic K-Ras maintains the nucleotide pool via the MAPK-dependent signaling pathway, leading to MYC upregulation, and the use of MEK inhibitors reduces the incorporation of glutamine-derived nitrogen into purine nucleotides 38

These microbial alterations were accompanied by functional impairments, with CMS significantly reducing SCFA production, particularly acetic and propionic acid concentrations (Tyagi et al., 2025)

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30 Billion TFU Akkermansia muciniphila A cutting-edge probiotic strain known for its role in gut barrier integrity, healthy metabolism*