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The human trial data for both peptides were generated with characterized clinical product

Brain 123, 16671676

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These observations highlight the suitability of the HepG2 model to study these events and the necessity to define cellular sensors and signaling cascades involved in the NFT-induced increase of glutathione levels

The ideal dosage of sacubitril/valsartan in dogs is unknown, but it appears that higher dosages than previously reported are tolerated and may be associated with improved clinical responses