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The reward circuit and related structures may participate in the interactions between the GLP-1 pathway and psychoactive substances, as GLP-1Rs are expressed in key brain regions like the ventral tegmental area (VTA) and the nucleus accumbens (NAc) that control reward behaviors [54]

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Pataky MW, Womack CJ, Saunders MJ, Goffe JL, DLugos AC, El-Sohemy A et al (2016) Caffeine and 3-km cycling performance: effects of mouth rinsing, genotype, and time of day