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Further, the CVOTs in general also suggested a potential benefit of GLP-1 RAs on HF, positioning GLP-1 RAs as another advanced option alongside SGLT2 inhibitors in the otherwise sparse treatment armamentarium for especially HFpEF

Individual variation matters enormously with any of these medications, and understanding why some people do not lose weight on semaglutide helps set realistic expectations

Elimination - Following a [3H]-liraglutide dose, intact liraglutide was not detected in urine or feces

An injection of semaglutide is given once per week

But the higher doses required for weight loss (absent a diabetes diagnosis) create more side effects, and at the end of the day, they arent cost-effective