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Escalate: Increase by 24 mg every 4 weeks as tolerated
In Phase 1 and Phase 2 human studies (20222023) subjects showed weight reductions of up to 24 % of baseline over 48 weeks
Clinical implication Considering the potential for gastric food retention and aspiration risks associated with surgical or endoscopic interventions, the American Society of Anesthesiologists recommends the discontinuation of short-acting GLP-1 RAs one day and long-acting formulations at least 1 week before surgical procedures [27]
The additional receptors in retatrutide increase metabolic rate, enhance fat breakdown, and reduce nausea while providing the same appetite suppression and gastric slowing as Ozempic
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