A study of humans with a genetic mutation for CYP2R1, or those done using CYP2R1 knockdown mouse models, demonstrate low circulating levels of 25(OH)VD 3 24
Similar findings were discovered in preclinical animal models of lung cancer (199), in which most tumor-specific CD8+ T cells in the TDLNs are functional and exhibit a gene expression signature resembling that of stem-like CD8+ T cells (199), suggesting that the antigen presentation and T cell priming in TDLNs is critical for the ICB treatment
10.3389/fnins.2023.1187758 11 AlievG.BeerakaN
Moradi M, Mojtahedzadeh M, Mandegari A, Soltan-Sharifi MS, Najafi A, Khajavi MR, Hajibabayee M, Ghahremani MH
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