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Dosing is typically 250-500mcg twice daily for injectable, or 500-1,000mcg daily for oral

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Many people who take semaglutide experience gastrointestinal side effects

TRIUMPH-4 (December 2025): Topline results from the Phase 3 TRIUMPH-4 investigational trial evaluating the triple hormone receptor agonist in adults with obesity or overweight and knee osteoarthritis, without diabetes, met all primary and key secondary endpoints, with substantial reductions in body weight and improvements in knee pain and physical function also observed

Some may find that once menopause-related symptoms like insomnia and mood changes resolve, they can maintain their weight loss without ongoing treatment