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Researchers should note that despite GHK-Cus favorable safety profile, the subcutaneous or intramuscular administration of peptides in general is associated with injection site pain, lightheadedness, nausea, and even flu-like symptoms in subjects

Salah, M., Abdelsamie, A

In plasma, GHK-Cu is approximately 200 ng/ml at 20 years of age, but drops to 80 ng/mL by the age of 60

These play a significant role in neurotransmitter production, inflammation control and barrier regulation and their depletion is frequently observed in individuals with depression and anxiety further suggesting their relevance to mental health (Xiong R.-G

In the liver, S1PR2 activates pro-insulin signaling through enhancing insulin-degrading enzyme (IDE), thereby potentially alleviating insulin resistance associated with T2DM and AD based on animal mechanistic studies (Vettorazzi et al., 2017