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Synthetic peptides are engineered to improve bioavailability, target selectivity, and half-life, often surpassing the pharmacokinetic limitations of natural peptides. Vlieghe et al., Drug Discovery Today Do Natural and Synthetic Peptides Have Different Clearance Times

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While we observed a trend of slightly increased intracellular cAMP levels in SGBS cells without GPR146, SVF cells upon GPR146 knockdown exhibited significantly decreased cAMP levels compared to control cells (Fig