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The central clinical idea: when mitochondrial ATP production falls and oxidative stress rises, the brain may lose the energy and antioxidant reserve needed to regulate neurotransmission, maintain cell membranes, recycle methionine, produce SAM, clear adenosine and homocysteine, build glutathione and tolerate medications or supplements

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ASSD Autism or Autism Spectrum Disorder a method for at least partially treating, preventing, or ameliorating symptoms of Autism or Autism Spectrum Disorder (ASD) in a subject having, suspected of having, or at risk of developing, Autism or ASD comprising: optionally, subjecting the subject to testing to determine Autism or ASD status of the subject, thereby identifying the subject as being in need of treatment

For fragment [1,3 A - ] ( d,e,f ) and fragment [1,3 A + ] ( g,h,i ) comprising C 4 , the incorporation of an O 18 label is not observed, while fragment [0,2 A-H2O] + ( g,h,i ), including C 3 , contains an O 18 label supporting formation of flavan-3,3,4-triol ( 4 )