Think of the peptide as a key and the receptor as a lock: constant use wears the mechanism, and a planned off period lets it resensitize
This means that any excess B12 your body doesn't need is simply flushed out through your urinary system
Individuals with sensitive digestive systems or undergoing intensive treatments like chemotherapy can especially benefit
In osteoblasts lacking classical ER and ER, the expression and activation of GPER can mediate the biological effects of estrogen, demonstrating its key role in bone metabolism [143, 147]
Boonen S, Rosen C, Bouillon R, Sommer A, McKay M, Rosen D, Adams S, Broos P, Lenaerts J, Raus J, Vanderschueren D, Geusens P