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The article names a history of medullary thyroid carcinoma, a personal or family history of MEN2 syndrome, and severe gastroparesis as reasons to avoid GLP-1 agents entirely and to ask a provider about alternative treatments

Several hypothetical mechanisms might explain these anecdotal reports, though these remain speculative and not clinically proven for semaglutide: Dehydration represents a plausible contributing factor

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This structural difference makes injectable semaglutide considerably safer for levothyroxine users than oral formulations would be