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The GLP1R gene variant rs6923761 and FTO variant rs9939609 affect taste receptor expression and brain reward signaling, determining whether you're more or less likely to experience flavor shifts

10.1371/journal.ppat.0020092 37 DionyssiouD.DemiriE.TsimponisA.SarafisA.MpalarisV.TatsidouG.et al (2016)

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Tirzepatide patients lost an average of 1.1% more lean body mass after three months and 2% after 12 months of continuous use, the analysis by Massachusetts-based data analytics firm nference found