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Needed for bone growth and bone remodeling by osteoblasts and osteoclasts Prevention of rickets in children and osteomalacia in adults Together with calcium, vitamin D also helps protect older adults from osteoporosis

Accumulation of macrophages within the renal interstitial spaces, induction of heme-oxygenase, and the presence of a pro-oxidant environment (Agarwal et al., 1996

The twice-weekly injection schedule provides pharmacokinetic profiles similar to weekly dosing but may offer advantages for individuals who respond better to more frequent dosing intervals

Bacteriostatic water extends this to approximately four weeks by preventing microbial growth