[DOI] [PubMed] [Google Scholar] 115.Scorza C.A., Cavalheiro E.A., Calderazzo L., de Almeida A.C.G., Scorza F.A
To improve the selection of patients with the clinical rule and create less unnecessary alerts, prospective research into risk factors such as malnutrition, sepsis, liver and renal failure is needed
Additionally, 6 vital organs (heart, liver, spleen, lung, kidney, and brain) were isolated to calculate the organ index and observe histopathological changes
However, drugs targeting p53 are still under investigation in early clinical trials and have not been approved for clinical use
Implications for dosing frequency Despite the short serum half-life, daily (rather than multiple-times-daily) dosing has been shown adequate in most BPC-157 rodent studies