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Quick Answer: GLP-1 medications typically make you feel cold due to weight loss reducing body insulation and metabolic heat production, rather than through direct drug effects
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Each compound offers distinct advantages depending on the research question
PlexusDx's Precision Peptide Genetic Test ($99 add-on after your first month) analyzes your genetic variants in key pathways like the GLP1 receptor (rs6923761), GIPR (rs1800437), FTO (rs9939609), and MC4R (rs17782313) to map how your body's peptide signaling works
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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