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The use of L-carnitine in patients with nonalcoholic steatohepatitis and concomitant obesity contributes to the steady reduction of the main clinical and biochemical symptoms of nonalcoholic steatohepatitis

The engineering is three pieces: an Aib8 substitution that blocks DPP-IV cleavage at the vulnerable N-terminal site, an Arg34 substitution that reduces a second clearance pathway, and a C18 fatty diacid linker that binds serum albumin and tethers the peptide to a carrier protein large enough to slow renal filtration

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