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This contraindication stems from observations in rodent studies where semaglutide and other GLP-1 receptor agonists caused dose-dependent and treatment-duration-dependent thyroid C-cell tumors

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Finally, frequency of GSTP1 aberrant methylation in diffuse large B-cell lymphoma (DLBCL) also led to studies to validate the prognostic impact of such epigenetic alteration in these lymphomas

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