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PubMed: 33965067 Mechanistic Insight: The synergistic effect likely results from complementary appetite suppression pathways (GLP-1R in hypothalamus/hindbrain vs
To capture the slower more subtle interstitial uptake in AD, longer scan times are required to increase signal to noise ratio (SNR, Box 1) (Raja et al., 2018)
However, similar to other chronic diseases such as T2D, the focus in obesity management (including pharmacotherapy prescription) over time will need to be shifted to primary care and collaborative integrated care models to be developed between specialist obesity services and primary care striving to meet the needs of people living with obesity [115]
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