constipated on glp 1 Starting GLP-1 and feeling constipated? 👀 You're not alone. This can happen in the early stage of treatment — and it's exactly why doctor guidance matters from day one 💚 At our GLP-1 Constipation: Miralax vs Metamucil

32,33 Under physiological conditions, besides the paracrine secretion pathway in the gastrointestinal tract, most endogenous GLP-1 in circulation is locally deactivated by DPP-4 and the liver, 34 making it difficult to directly enter the CNS through the blood-brain barrier

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