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Ca 2+ -permeable AMPA and NMDA receptor channels in basket cells of rat hippocampal dentate gyrus

During the 26- to 78-week treatment periods in 5 clinical trials in adults with type 2 diabetes mellitus [see Clinical Studies (14.2, 14.3)] and 1 clinical trial in Japanese adults with type 2 diabetes mellitus, 14/2,924 (0.5%) of semaglutide tablet-treated patients developed anti-semaglutide antibodies

However, some severe side effects require immediate medical assistance

Troesch B, Hoeft B, McBurney M, Eggersdorfer M, Weber P

The TAA + Remo 50 mg/kg group demonstrated robust immune-staining of SIRT1 and weak immune-expression of NF-kB p65 (Figure 8d)