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These reviews focused more on animal experiments and did not sort out the heterogeneous results and related mechanisms produced in clinical research, so as to provide more high-quality evidence and systematic summary

additional studies to evaluate the differences in adherence to combination therapy with GLP-1RA and SGLT2i compared with SGLT2i monotherapy and how these differences impact outcomes are needed

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Mounjaro (tirzepatide): the newest option Mounjaro is a dual GIP and GLP-1 receptor agonist, the first of its kind, and is now approved for weight management in Ireland