For example, several inorganic nanomaterials, including metal chalcogenide nanoparticles, hybrid metal nanoparticles, and single-atom metal nanoparticles, can act as GSH peroxidase-mimicking nanozymes to exhaust intracellular GSH in cancer cells ( 2 O 2 , realizing tumor-specific catalytic therapy with response to the TME featuring overexpressed GSH and H 2 O 2 (Yin et al., 2019)
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doi: 10.1016/j.molmed.2014.02.007 116 RattilaSDunkCEEImMGrichenkoOZhouYYanez-MoMet al