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In some embodiments, the otic formulation or composition comprises about 2% by weight of the povidone

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One could hypothesize that these endoperoxide drugs accumulate and act on targets that lead to the production of reactive oxygen species, which ultimately affect cytosolic GSH levels

One characteristic of cancer is metabolic reprogramming, which provides tumor cells the basic elements for fast cell growth and maintains cell survival under hypoxic or nutrient-deficient conditions (Yoshida, 2015)