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A lymphocytic infiltrate and melanophages follow this in the papillary layer of the dermis (235, 238, 239)

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Figure 2e shows that UPLC-ESI-MS-MS additionally confirms the presence of intracellular bilirubin through comparison between the ion fragments pattern in the MS-MS spectra of bilirubin standard and the endothelial cellular fraction, both obtained after collision-induced fragmentation of pseudo-molecular ion (583.3 [MH + ] )