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This may lead to subsequent physiological abnormalities including gut dysbiosis and systemic inflammation, eventually resulting in a pathological clotting system, chronic endothelialitis, vasoconstriction, and hypoxia, as found in similar conditions such as heat stroke (183)

In this pathway, oxidative stress can trigger the release of cytochrome c from mitochondria into the cytosol

Oxidative stress occurs when the body is no longer able to 'mop up' excess free radicals, pro-oxidant molecules that 'rust' our cells and make them age faster

Zayed MNJ, Schumacher N, Misk MS, Dhar

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