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In a majority of patients, it is precipitated by a reduction or discontinuation of insulin, following starvation or low carbohydrate diet, urosepsis, dehydration, severe acute illness, heavy physical exercise, or excessive alcohol intake

These dietary changes alone can contribute to constipation, particularly if fiber intake is reduced

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Compounding pharmacies source retatrutide from chemical suppliers, reconstitute it under sterile conditions, and ship it to clinics or directly to patients under prescriber oversight

The practical result is a compound that reduces energy intake through appetite suppression while simultaneously increasing energy expenditure