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& Di Lorenzo, M

This mechanism reduces food intake and hunger signaling independent of their blood sugar-lowering effects, making them effective for weight management in non-diabetic populations

Available at: Sanyal AJ, Kaplan LM, Fras JP, Brouwers B, Wu Q, Thomas MK, et al

Clinical trials revealed improved glycemic control in diabetic patients and substantial weight loss

Despite promising preclinical data, targeting lipid peroxidation in clinical trials has not been successful [90], indicating that additional research exploring BBB penetrance of potential therapeutics and a better understanding of how lipid peroxides work in the temporal/biological context of TBI will be necessary before these metabolites can be harnessed for clinical benefit