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Initial treatment included acitretin (to regulate keratinization), topical tretinoin cream, sodium thiosulfate (for pruritus relief), and metformin (1,000 mg daily for glycemic control)

By the time you are finally diagnosed, you might already be dealing with issues such as memory changes, fatigue, tingling in their feet and hands, and a very strong sense that your body has been changing without any explanation

The amplitude of NAD reduction increased slightly with the duration of illumination ( Figure 4D )