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Biochim Biophys Acta Mol Cell Res

They produce the alpha-melanocyte stimulating hormone (alpha-MSH) that binds to the melanocortin 3 and 4 receptors (MC3Rs and MC4Rs) expressed by the second order neurons located in the periventricular nucleus and the lateral hypothalamic area (LHA) (51) (Figure 1)

Publications reporting experimental, clinical, and ethnopharmacological evidence were also considered

Despite longer duration of treatment, no significant weight loss was observed

Melanotan-1 is a linear 13-amino acid chain (molecular weight 1646.85 Da), while Melanotan-2 is a cyclic 7-amino acid peptide (1024.18 Da) with a lactam bridge between positions 4 and 10